'Vision Zero' was first implemented in Sweden in the 1990s and is being adopted by councils in the UK.
Oxfordshire County Council has become one of a growing number of authorities, committing to Vision Zero for road deaths and serious injuries.
It aims to ensure there are NO casualties on the roads by 2050.
Before that, the council wants to reduce cases by a quarter by 2026, and 50% by 2030.
It will look at everything from infrastructure and behaviour, to technology and legislation, to achieve that.
Although the total number of reported road casualties in Oxfordshire has fallen over the past 10 years, road deaths have remained unchanged, with an average of 25 per year.
In recent years, the annual average total of serious injuries in the county has been 210.
Councillor Andrew Gant, Oxfordshire County Council's Cabinet Member for Highways Management, said: "Recent tragic incidents on our roads have focused everyone's minds on the vital importance on making our roads and streets safer for all users - especially the most vulnerable.
"The adoption of a Vision Zero approach for Oxfordshire signals a clear ambition and commits the council to taking a new approach. But we can't achieve this alone. It will require close working with partners and stakeholders to look at infrastructure, behaviour, technology and legislation to achieve this change."
Vision Zero was first implemented in Sweden in the 1990s and has proved successful across many large European cities.
An initial sum of £250,000 from reserves has been identified for the delivery of prioritised Vision Zero initiatives to support vulnerable road users in Oxfordshire
Dr Alison Hill, Chair of cycling campaign group Cyclox, which is part of the cycling safety working group, said: "To eliminate deaths and serious injury on our roads is going to require huge commitment and a change in approach from the council and its partners.
"We need to design out danger, particularly for people who cycle and walk. We need to take action now. We owe it to the families of those who have been killed and have suffered life changing injuries on Oxfordshire's roads."